Which of the following signs may often indicate imminent labor?

The loss of the mucous plug is a significant sign that may indicate imminent labor. The mucous plug acts as a protective barrier for the cervix during pregnancy, sealing it and preventing bacteria from entering the uterus. As labor approaches, hormonal changes cause the cervix to soften and dilate, which can lead to the expulsion of the mucous plug. This discharge can vary in appearance, often described as thick and clear or slightly bloody, and is often referred to as "show." Loss of the mucous plug can signal that the body is preparing for labor, indicating that the onset of contractions and active labor may occur soon.

Other signs, such as an increase in fetal movements, heightened anxiety, or spotting, may not specifically indicate imminent labor. While increased fetal movements can reflect a healthy fetal response, they do not necessarily correlate with the onset of labor. Heightened anxiety can occur at various stages during pregnancy, particularly as the due date approaches, but it is not a definitive sign of labor. Spotting may occur due to a variety of reasons, including cervical changes or irritation, but it is not a consistent indicator of labor approaching imminently.